Dr. Lisa Briand received her doctorate in neuroscience from University of Michigan, where she worked with Dr. Terry Robinson investigating the effect of chronic cocaine use on cognitive function. Dr. Briand completed a postdoctoral fellowship at the University of Pennsylvania in the laboratories of Dr. Julie Blendy and Dr. Chris Pierce studying the circuitry and physiological mechanisms underlying reinstatement of cocaine seeking. Her current research program extends these findings to examine the electrophysiological mechanisms underlying drug relapse. Specifically, her research program examines the role of AMPA receptor trafficking in the ability of cues and stress to elicit relapse to cocaine seeking. Her research is currently funded by the National Institute of Drug Abuse.


Selected Publications

  • Polter, A.M., Bishop, R.A., Briand, L.A., Graziane, N.M., Pierce, R.C., & Kauer, J.A. (in press). Post-stress block of kappa opioid receptors rescues LTPGABA and prevents reinstatement of cocaine seeking. Biological Psychiatry. PMID: 24957331
  • Briand, L.A., Kimmey, B., Ortinski, P.I., Huganir, R.L., & Pierce, R.C. (2014). Selective deletion of glutamate receptor interacting protein within the nucleus accumbens increases vulnerability to cocaine relapse. Neuropsychopharmacology 39: 759-69. PMID: 24126453
  • Gundersen, B.B., Briand, L.A., Onksen, J.L., LeLay, J., Kaestner, K.H., & Blendy, J.A. (2013). Increased hippocampal neurogenesis and accelerated response to antidepressants in mice with specific deletion of CREB in the hippocampus: Role of CREM tau. Journal of Neuroscience 33: 13673-85. PMID: 23966689
  • Briand, L.A. and Blendy, J.A. (2013). Not all stress is equal: The role of CREB in the ability of restraint stress to elicit reinstatement of cocaine-conditioned reward. Behavioural Brain Research. 246: 63-68. PMID: 23458740
  • Turner, J.R., Ecke, L.E., Briand, L.A., Haydon, P.G., Blendy, J.A. (2013). Cocaine-related behaviors in mice with deficient gliotransmission. Psychopharmacology,226: 167-76. PMID: 23104263
  • Graziane, N.M., Polter, A.M., Briand, L.A., Pierce, R.C., Kauer, J.A. (2013). Kappa opioid receptors regulate stress-induced cocaine seeking and synaptic plasticity of VTA GABAergic synapses. Neuron. 77: 942-954. PMID: 23473323
  • Onksen, J.L., Briand, L.A., Galante, R.J., Pack, A.L., Blendy, J.A. (2012). Running-induced anxiety is dependent on increases in hippocampal neurogenesis. Genes, Brain and Behavior, 11: 529-38. PMID: 22471438
  • Briand, L.A., Lee, F.S., Blendy, J.A. and Pierce, R.C. (2012). Enhanced Extinction of Cocaine Seeking in Brain Derived Neurotrophic Factor Val66Met Knock-in Mice. European Journal of Neuroscience, 35: 932-9. PMID: 22394056
  • Briand, L.A., Vassoler, F.M., Pierce, R.C., Valentino, R.J. and Blendy, J.A. (2010). Ventral tegmental afferents in stress-induced reinstatement: the role of cAMP response element-binding protein. Journal of Neuroscience, 30:16149-59. PMID: 21123561
  • Briand, L.A. and Blendy, J.A. (2009). Molecular and genetic substrates linking stress and addiction. Brain Research, 1314:219-34. PMID: 19900417Kreibich, A.S., Briand, L., Cleck, J.N., Ecke, L., Rice, K.C. and Blendy, J.A. (2009). Stress-induced potentiation of cocaine reward: a role for CRF R1 and CREB. Neuropsychopharmacology, 34:2609-17. PMID: 19675537
  • Briand, L.A., Gross, J.P. and Robinson, T.E. (2008). Impaired object recognition following prolonged withdrawal from extended access cocaine self-administration. Neuroscience, 155: 1-6. PMID: 18590801
  • Briand, L.A., Flagel, S.B., Garcia-Fuster, M.J., Watson, S.J., Akil, H., Sarter, M., and Robinson, T.E. (2008). Persistent alterations in cognitive function and prefrontal dopamine D2 receptor expression following extended (but not limited) access to self-administered cocaine. Neuropsychopharmacology, 33: 2969-80. PMID: 18305460Briand, L.A., Flagel, S.B., Seeman, P., and Robinson, T.E. (2008). Cocaine self-administration produces a persistent increase in dopamine D2(High) Receptors. European Journal of Neuropsychopharmacology, 18: 551-6. PMID: 18284941
  • Briand, L.A., Gritton, H., Howe, W.M., Young, D.A. and Sarter, M. (2007). Modulators in concert for cognition: modulator interactions in the prefrontal cortex. Progress in Neurobiology, 83: 69-91. PMID: 17681661
  • Briand, L.A., Robinson, T.E. and Maren, S. (2005). Enhancement of auditory fear conditioning after housing in a complex environment is attenuated by prior treatment with amphetamine. Learning & Memory, 12: 553-6. PMID: 16287722
  • Diamond, A., Briand, L.A., Fosella, J. and Gehlbach, L. (2004). Genetic and Neurochemical Modulation of Prefrontal Cognitive Functions in Children. American Journal of Psychiatry, 161: 125-32. PMID: 14702260

Courses Taught

  • Neuropharmacology of Substance Abuse